TRT (testosterone replacement therapy) is one specific type of HRT (hormone replacement therapy). HRT is the umbrella term for replacing any deficient hormone — testosterone, estrogen, progesterone, thyroid, or others. TRT refers only to restoring testosterone to a healthy range, most commonly in men (though women produce and can need testosterone too). Put simply: all TRT is HRT, but not all HRT is TRT.
What is TRT?
Testosterone replacement therapy restores testosterone to an optimal physiologic range using injections, creams/gels, or pellets. It is prescribed for men (and some women) with lab-confirmed low testosterone plus symptoms like fatigue, low libido, brain fog, weight gain, poor recovery, and low mood. Treatment is guided by bloodwork and adjusted over time.
What is HRT?
Hormone replacement therapy is the broader category of restoring any hormone that has fallen out of balance. For women, HRT often means estrogen and progesterone during perimenopause and menopause. For men, the most common form of HRT is TRT. HRT can also include thyroid support, DHEA, and peptides depending on your labs and goals.
TRT vs HRT: the key differences
- Scope: TRT = testosterone only. HRT = any hormone (estrogen, progesterone, thyroid, testosterone, etc.).
- Who it’s for: TRT is most common in men with low T; HRT for women usually addresses menopausal estrogen/progesterone decline.
- Goal: Both aim to restore hormones to a healthy, symptom-relieving range — guided by labs, not guesswork.
Which is right for you?
It depends on your symptoms and bloodwork. Men with low testosterone typically start with TRT; women in perimenopause/menopause typically start with estrogen/progesterone-based HRT (and sometimes low-dose testosterone). A physician review of your labs is the only way to know for sure.
How MultiGen Wellness works
MultiGen Wellness is a physician-led telehealth practice offering both TRT and broader HRT for men and women in all 50 states. New patients start for $247 (regularly $497), which includes your first physician visit; follow-up visits are $97, and prescriptions ship to your door. Call 1-800-259-0015 or explore testosterone replacement therapy and hormone therapy for men and women.
Frequently asked questions
Is TRT the same as HRT?
TRT is a subtype of HRT. HRT replaces any deficient hormone; TRT replaces testosterone specifically.
Can women do TRT?
Yes. Women produce testosterone and some benefit from low-dose testosterone as part of their HRT, alongside estrogen and progesterone when indicated.
Do I need labs first?
Yes. Both TRT and HRT are prescribed based on bloodwork plus symptoms, then monitored over time.
Related reading
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