PT-141 is the research name for bremelanotide, a medication that works on the brain to increase sexual desire. An FDA-approved version (Vyleesi) treats low sexual desire in women before menopause, and providers also prescribe it off-label for men and for women after menopause. MultiGen Wellness prescribes compounded PT-141 as an injection, as a nasal spray with oxytocin, or as a dissolving tablet combined with tadalafil and oxytocin.
PT-141 at a glance
| What it is | A synthetic peptide that activates melanocortin receptors in the brain involved in desire and arousal. |
|---|---|
| Forms we prescribe | Injection (vial), nasal spray with oxytocin, and a sublingual tablet that combines PT-141 with tadalafil and oxytocin. |
| How it’s taken | As needed, before sexual activity. The Vyleesi label says to inject it at least 45 minutes beforehand. |
| FDA status | Vyleesi was FDA-approved in 2019 for acquired, generalized low sexual desire in premenopausal women. Compounded PT-141 and use in men are not FDA-approved. |
| Controlled substance | No. |
| Cost | Medication is priced separately from visits. See current prices on our pharmacy page. |
How PT-141 differs from Viagra and Cialis
Sildenafil (Viagra) and tadalafil (Cialis) increase blood flow. They help the body respond, but they don’t create desire, so they work best when interest is already there. PT-141 works on the other side of the equation: it acts on melanocortin receptors in the brain that are involved in sexual motivation. That’s why some products combine the two, so one ingredient supports desire and the other supports blood flow.
What the studies show
Bremelanotide was approved based on two Phase 3 trials called RECONNECT, with about 1,200 premenopausal women. Compared with placebo, it modestly improved desire and reduced distress about low desire. It did not significantly increase the number of satisfying sexual encounters, so it helps some people more than others.
Earlier, smaller studies in men with erectile dysfunction found better erectile response, including in some men who hadn’t done well on sildenafil. Those studies were not large enough for FDA approval in men.
Side effects
- Nausea is the most common side effect. In the trials, about 40% of women had it, usually with the first doses, and it often eased with later doses.
- Flushing, headache and redness at the injection site
- A temporary rise in blood pressure and drop in heart rate after a dose, which can last up to 12 hours
- Darkening of patches of skin on the face, gums or breasts, more likely with frequent use
The Vyleesi label limits use to one dose in 24 hours and no more than 8 doses a month.
Who should not use PT-141
- Anyone with uncontrolled high blood pressure or known heart disease
- Women who are pregnant or trying to become pregnant
- People taking naltrexone by mouth for alcohol or opioid dependence, since bremelanotide can lower naltrexone levels
Low desire has causes worth checking
Low libido is often hormonal. In men it’s one of the most common signs of low testosterone. In women, falling estrogen, progesterone and testosterone around menopause play a big part. Thyroid problems, high prolactin and some antidepressants can also lower desire. Labs can show whether a hormone problem is behind it, which may matter more than any single medication. See testosterone therapy for men, women’s hormone therapy and our sexual health page.
How to get PT-141 through MultiGen Wellness
- Book a free 15-minute consult. Pick a time online or call 1-800-259-0015. We go over your symptoms, goals and medical history.
- Labs and a provider visit. A licensed provider reviews your history and lab results and decides whether PT-141 is a safe fit. Getting started is $247, which includes your first provider visit. Follow-up visits are $97 each, with no monthly membership.
- Medication shipped to your door. If it’s prescribed, a state-licensed partner pharmacy ships it to you. Your provider follows up with labs and visits to adjust the plan.
Frequently asked questions
Does PT-141 work for men?
It is not FDA-approved for men, but smaller studies in men with erectile dysfunction found it improved erections, and providers prescribe it off-label. It is often combined with tadalafil for men.
How long does PT-141 last?
Effects usually start within about an hour and can last several hours. The label calls for no more than one dose in 24 hours.
Can I take PT-141 with Cialis?
Yes, they are often combined, and one of the forms we prescribe is a single tablet with both. Your provider checks your blood pressure and heart history first, since both can affect blood pressure.
Is PT-141 the same as Melanotan?
They are related. PT-141 was developed from melanotan II research, but it was designed to focus on desire, not tanning. Melanotan II is not an approved drug.
Other medications we prescribe
This page is for education and isn’t medical advice. Only a licensed provider who has reviewed your history and labs can decide whether a medication is right for you. Availability depends on your state. Last reviewed November 7, 2026.
Want to talk it through with our team?
Book a free 15-minute video consult. $197 if you sign up the same day as your consult, normally $247, and that includes your first doctor visit. No membership.